• Power station, a facility for the generation of electric power
• The Power-House, a 1916 novel by John Buchan
• Powerhouse (comics), the name of several fictional characters in the Marvel Comics Universe
• Powerhouse Museum, a science and technology museum in Sydney, Australia
• Powerhouse (programming language), a 1980s programming language by Cognos Corporation
• Powerhouse (TV series), a United States television series
• Powerhouse (video game), a 1995 computer game by Impressions Games, now part of Vivendi SA
• Brisbane Powerhouse, a performing arts center in Brisbane, Queensland, Australia
• Powerhouse, a large function centre and club overlooking Albert Park Lake in Melbourne, Victoria, Australia, after which many local recreational clubs are named
• Dick Smith Powerhouse, a chain of large electronics stores operating in Australia and New Zealand
• A brand of chocolate bar manufactured by Peter Paul
• Powerhouse (band), an electronic musical group
• "Powerhouse", a short story by Eudora Welty

In music

• Eric Clapton's Powerhouse, a short-lived 1960s blues band
• Powerhouse (album), a 2005 album by Mustasch.
• Powerhouse (Deep Purple album), a 1977 album by Deep Purple
• Powerhouse (Whiteheart album), a 1990 album by Whiteheart
• Powerhouse (band), the name of several dance music projects
• Powerhouse (song), a composition by Raymond Scott featured in many Warner Bros. cartoons
• Powerhouse (club), a Rock and Metal club in Shifnal, Shropshire
• Powerhouse (TKR album), a 1991 album by The Kinsey Report