At the time the French established Fort Caroline, the Potano were at war with the Northern Utina. The French supported the Northern Utina and helped defeat the Potano. After Spain expelled France from Florida, it also supported the Northern Utina. In 1584 a Spanish captain was killed when he led an invasion into Potano territory. A second Spanish expedition killed many Potanos and drove the rest from their towns.
In the 1590s Franciscan missionaries reached the Potano, first with visits by an itinerant missionary, and in 1609 with a mission, San Francisco de Potano. Other missions soon followed, with five in Potano territory by 1633. The Franciscans reported in 1602 that they were teaching the catechism to over one thousand Potanos.
In 1656 the Potano participated in the Timucuan rebellion against the Spanish authorities. The Spanish prevailed after eight months. Most Timucuan towns and missions were burned during the fighting. After the rebellion, the Potano missions were re-established. The Potano were badly affected by an unidentified disease in 1672. One estimate puts the population of the Potano at 3,000 in 1650. By 1675, there were 160 people at the two remaining Potano missions.
Following the Timucuan rebellion, many land grants were made by the Spanish in areas no longer used by the reduced population. There is evidence of twenty-five Spanish-owned cattle ranches in Timucuan territory, including several in Potano territory. Much of the evidence for these ranches consists of complaints to Spanish officials that cattle were running loose and eating village crops.
By 1685 tribes from north of Florida, encouraged, supplied and often joined by whites from the Province of Carolina, were raiding into Potano territory, burning villages, killing some Potanos and carrying others away to be sold as slaves in Charles Towne. These raids continued into the 18th century. The Spanish mission system across northern Florida collapsed after 1704. Some surviving Potano may have reached the missions at St. Augustine, but the Potano effectively disappeared from history at that time.
- retrieved March 31 2006