The diagnostic criteria of this family are:
Currently there are a number of genera recognised in this family. Like many of the protist groupings these may be significantly revised in light of findings from the DNA sequences. While more complete listings of the vertebrate host species can be found on the genus pages, typical hosts are given here.
Biguetiella - bats Billbraya Bioccala - bats Dionisia - bats Haemoproteus - birds Hepatocystis - bats, monkeys, hippopotamus, squirrels Leukocytozoon - birds Mesnilium - fish Nycteria - bats Plasmodium - mammals, birds and reptiles Polchromophilus - bats Rayella - flying squirrels Saurocytozoon - reptiles