The most usually noted expedition is the Pitt River Expedition, in California, April 28 to September 13, 1850.
US Civil War Officer and General George Crook is noted as having led the Pitt River Expedition in as a 1st lieutenant in 1857 In one of the several engagements he was severely wounded by an Indian arrow.
The State of California notes expenditures in documentation for the California Militia and “Expeditions Against the Indians”, 1850 - 1859; which makes note of a Pitt River Expedition in 1859 