Pilkington is a surname, and may refer to:
- Sir Alastair Pilkington (1920-1995), British industrialist
- Brian Pilkington, English footballer
- Charles Pilkington, British Mountaineer, and explorer of the Skye Cuillin
- Edith Pilkington Karr, first wife of Sir Henry Seton Karr (1853-1914), British politician, author, hunter and member of parliament
- Francis Pilkington (ca 1565-1638), English composer, lutenist and singer
- George Pilkington (born 1981), English footballer
- James Pilkington may refer to:
- Karl Pilkington (born 1972), English radio producer and personality
- Kevin Pilkington (born 1974), English footballer
- Laetitia Pilkington (c. 1709-1750), British poet
- Liam Pilkington, Irish activist
- Lorraine Pilkington (born 1975), Irish actress
- Peter Pilkington, Baron Pilkington of Oxenford (born 1933), British politician
- Sir Richard Antony Pilkington (1908-1976), British Conservative politician
- Robert Rivington Pilkington (1870–1942), Irish politician
- John Pilkinton, British explorer
- Aaron Michel Pilkington (1990- Present) President of Thespians and son of Albert Walton Pilkington III