Piero del Ponte (died 1535) was a member of the Order of the Knights Hospitaller.
He hailed from Piedmont (Italy) and was a descendent of the ancient family of Casal-Gros and Lombriax. He was the Order's governor of the island of Lango when Rhodes fell to the Ottomans on New Year's Day 1523 and was still there in 1534 when he received the news of his election to the office of Grand Master of the Order, to succeed Philippe Villiers de L'Isle-Adam at Malta.
Del Ponte died on 18 November 1535, 15 months after his election. He was buried in the chapel of Our Lady of Victories, in Fort St. Angelo, Birgu, Malta. Eventually his remains were interred in the crypt of St. John's Co-Cathedral in Valletta, Malta.