Pfiesteria piscicida is a dinoflagellate species of the genus Pfiesteria that some researchers claim is responsible for many harmful algal blooms in the 1980s and 1990s on the coast of North Carolina and Maryland. The species name piscicida means "fish-killer."
Early research suggested a very complex life cycle of Pfiesteria piscicida with up to 24 different stages, spanning from cyst to several amoeboid forms with toxic zoospores. Transformations from one stage to another depend on environmental conditions such as the availability of food. However these results have become controversial as additional research has found only a simple haplontic life cycle with no toxic amoeboid stages and amoeba present on attacked fish may represent an unrelated species of protist.
With these criteria and environmental qualifiers (e.g., 20% of a 50-fish sample, all of the same species, have lesions caused by a toxin), it is likely that Pfiesteria-related surveillance data can better track potential illnesses.
Pfiesteria toxins have been blamed for causing adverse health effects in people who have come in close contact with waters where this organism is abundant. Since June 1997, the Maryland Department of Health and Hygiene has been collecting data from Maryland physicians through a state-wide surveillance system on illnesses suspected of being caused by Pfiesteria toxin. As of late October 1997, illness was reported by 146 persons who had been exposed to diseased fish or to waters that were the site of suspected Pfiesteria activity. Many of these persons are watermen and commercial fishermen.
The strongest evidence of adverse human health effects so far comes from case studies of two research scientists who were both overcome in their North Carolina laboratory in 1993. They still complain of adverse effects on their cognitive abilities, particularly after exercising. Duke University Medical Center researchers conducted experiments on rats, which showed that the toxin appeared to slow learning but did not affect memory.
Identification of a P2X7 Receptor in [GH.Sub.4][C.Sub.1] Rat Pituitary Cells: A Potential Target for a Bioactive Substance Produced by Pfiesteria Piscicida
May 01, 2001; We examined the pharmacologic activity of a putative toxin (pPfTx) produced by Pfiesteria piscicida by characterizing the...