To the west, the road adjoins Parks Road at a T junction with the Radcliffe Science Library just to the north. To the east, a cycle route continues to New Marston, crossing the River Cherwell. The road itself continues as St Cross Road after a sharp corner to the south, past Linacre College. About half way along South Parks Road, Mansfield Road adjoins to the south.
The road has been the scene of protests by animal rights protesters because of a new animal testing facility that is being built here. Pro-Test has been formed in reaction to the activities of the animal rights movement.