Southeast of Quanah and south of Chillicothe is the ghost town of Medicine Mound, which consists of two buildings. One is a restoration of a former general store which highlights the history of rural America. The curator is Myna Potts.
According to the United States Census Bureau, the city has a total area of 3.5 square miles (9.0 km²), all of it land.
There were 1,255 households out of which 29.2% had children under the age of 18 living with them, 51.8% were married couples living together, 10.4% had a female householder with no husband present, and 34.4% were non-families. 31.9% of all households were made up of individuals and 20.2% had someone living alone who was 65 years of age or older. The average household size was 2.35 and the average family size was 2.96.
In the city the population was spread out with 25.1% under the age of 18, 7.9% from 18 to 24, 22.0% from 25 to 44, 22.9% from 45 to 64, and 22.0% who were 65 years of age or older. The median age was 42 years. For every 100 females there were 87.6 males. For every 100 females age 18 and over, there were 83.2 males.
The median income for a household in the city was $26,354, and the median income for a family was $29,506. Males had a median income of $26,472 versus $18,403 for females. The per capita income for the city was $16,841. About 16.6% of families and 20.7% of the population were below the poverty line, including 29.8% of those under age 18 and 16.4% of those age 65 or over.