Hughie and Mumma Darcy live at Twelve-and-a-Half Plymouth Street in Surry Hills with their two teenaged daughters; Roie, a factory worker; and Dolour, who is still in school. Also residing in the house are the Darcy's tenants; Patrick Diamond, a Protestant Irishman; and Miss Sheily and her illegitimate adult son Johnny, who is mentally disabled. The novel follows their poor working class lives and those of their friends and neighbours.
In 1949 Ruth Park published Poor Man's Orange as a sequel to The Harp in the South. A prequel, Missus, was published in 1985.
The Harp in the South and Poor Man's Orange were both adapted into miniseries' in 1987.