Sen pursued his artistic training at the Academie Andre Lhote, the Academie la Grande Chaumiere, the Ecole des Beaux Arts, and the Ecole des Louvre in Paris. Upon his return to India, he taught first in Bihar and then at Jadavpur University.
In 1969 he was the recipient of the French Fellowship for Designing and Typeface and in 1970 he was awarded a Rockefeller Fellowship. Sen has exhibited widely both in India and abroad, including the Calcutta Group exhibition (1944), London (1962), Sao Paolo Biennale (1965), New Delhi Triennale (1968, 1971, 1975), Sweden (1984), and the Havana Biennale (1986).
Sen lives and works in Calcutta.