Although relatively uncommon, with the wide availability of single-component opiates and synthetic opioids, papaveretum is still used for moderate to severe pain and for pre-operative sedation. In the clinical setting, papaveretum is usually given by the subcutaneous, intramuscular or intravenous routes.
Prior to 1993, the preparation also contained noscapine, however this was removed from the BP formulation due to the genotoxic potential of noscapine.