The Italian faction wished to return the papacy to Rome, the Gascon faction—mostly composed of the relatives of the previous pope, Clement V, wished to retain the privileges and powers they had enjoyed during his rule, and the French/Provençal opposed these aims of the Italian and Gascon factions.
|Elector||Nationality||Faction||Cardinalatial order and title||Elevated||Elevator||Other ecclesiestical titles||Notes|
|Nicolò Albertini, O.P.||Prato||Italian||Cardinal-bishop of Ostia e Velletri||1303, December 18||Benedict XI||Dean of the Sacred College of Cardinals|
|Bérenger Frédol, seniore||French||"French"||Cardinal-bishop of Frascati||1305, December 15||Clement V||Grand penitentiary||Cardinal-nephew|
|Arnaud de Falguières||French||Gascon||Cardinal-bishop of Sabina||1310, December 19||Clement V|
|Guillaume de Mandagot, C.R.S.A.||French||"French"||Cardinal-bishop of Palestrina||1312, December 23||Clement V|
|Arnaud d'Aux||French||Gascon||Cardinal-bishop of Albano||1312, December 23||Clement V||Camerlengo of the Holy Roman Church||Cardinal-nephew|
|Jacques d'Euse||French||"French"||Cardinal-bishop of Porto e Santa Rufina||1312, December 23||Clement V||Elected Pope John XXII|
|Nicolas de Fréauville, O.P.||French||"French"||Cardinal-priest of the title of S. Eusebio||1305, December 15||Clement V||Protopriest|
|Arnaud Nouvel, O.Cist.||French||Gascon||Cardinal-priest of the title of S. Prisca||1310, December 19||Clement V||Vice-Chancellor of the Holy Roman Church|
|Bérenguer Frédol, iuniore||French||"French"||Cardinal-priest of the title of Ss. Nereo ed Achilleo||1312, December 23||Clement V||Camerlengo of the Sacred College of Cardinals||Cardinal-nephew|
|Michel du Bec-Crespin||French||"French"||Cardinal-priest of the title of S. Stefano al Monte Celio||1312, December 23||Clement V|
|Guillaume Teste||French||Gascon||Cardinal-priest of the title of S. Ciriaco alle Terme||1312, December 23||Clement V|
|Guillaume Pierre Godin, O.P.||French||Gascon||Cardinal-priest of the title of S. Cecilia||1312, December 23||Clement V|
|Vital du Four, O.F.M.||French||Gascon||Cardinal-priest of the title of Ss. Silvestro e Martino ai Monti||1312, December 23||Clement V|
|Raymond, O.S.B.||French||Gascon||Cardinal-priest of the title of S. Pudenziana||1312, December 23||Clement V|
|Giacomo Colonna||Roman||Italian||Cardinal-deacon of S. Maria in Via Lata||1278, March 12||Nicholas III||Protodeacon; archpriest of the Liberian Basilica||Uncle of Cardinal Pietro Colonna|
|Napoleone Orsini||Roman||Italian||Cardinal-deacon of S. Adriano||1288, May 16||Nicholas IV||Archpriest of the Vatican Basilica|
|Pietro Colonna||Roman||Italian||Cardinal-deacon of S. Angelo in Pescheria||1288, May 16||Nicholas IV||Archpriest of the Lateran Basilica; abbot of Subiaco||Nephew of Cardinal Giacomo Colonna|
|Guglielmo de Longhi||Bergamo||Italian||Cardinal-deacon of S. Nicola in Carcere Tulliano||1294, September 18||Celestine V|
|Giacomo Caetani Stefaneschi||Rome||Italian||Cardinal-deacon of S. Giorgio in Velabro||1295, December 17||Boniface VIII||Cardinal-nephew|
|Francesco Caetani||Rome||Italian||Cardinal-deacon of S. Maria in Cosmedin||1295, December 17||Boniface VIII||Cardinal-nephew|
|Luc Fieschi||Genoese||Italian||Cardinal-deacon of Ss. Cosma e Damiano||1300, March 2||Boniface VIII||Nephew of Pope Adrian V|
|Arnaud de Pellegrue||French||Gascon||Cardinal-deacon of S. Maria in Portico||1305, December 15||Clement V||Protector of the Order of Franciscans||Cardinal-nephew|
|Raymond Guillaume des Forges||French||Gascon||Cardinal-deacon of S. Maria Nuova||1310, December 19||Clement V||Cardinal-nephew|
|Bernard de Garves||French||Gascon||Cardinal-deacon of S. Eusebio||1310, December 19||Clement V||Cardinal-nephew|
Had the conclave taken place according to the rules prescribed by Clement V in Ne Romani (1312) and Pope Gregory X in Ubi periculum (1274), the cardinal electors would have had to meet in the diocese where the Curia was in residence (the place where letters and apostolic causes were heard), and the local magistrates would have had the authority to compel the departing cardinals to stay. Indeed, the election did begin in that location, the episcopal palace of Carpentras (north-east of Avignon), with 23 of the 24 eligible cardinals present (Fieschi was still in Italy).
The Italian cardinals opened by conclave by attempting to gain the support of the Provençal cardinals, proposing the candidacy of Languedocian jurist and fellow cardinal Guillaume de Mandagot (who had promised to restore the papacy to Rome and end the Gascon domination), whom the Gascons were able to defeat because of the personal opposition of Languedocian cardinal Berenguer Fredol, seniore. An impasse thereafter formed quickly and disputes between the servants of the Italian and Gascon cardinals broke out in the streets, aggravated by mercenary bands hired by the Gascon cardinal-nephews of Clement V and by the body of Clement V, still laying in the town square. Once the mercenaries openly besieged the conclave and the home in which the Italian cardinals were living, the Italian cardinals fled on July 24, 1314, and the rest of the College of Cardinals dispersed to Avignon, Orange, and Valence.
With both the Gascon and Italian cardinals threatening to hold their own elections (and thus begin another schism), Philip IV of France ("the Fair") convened a group of jurists to decide the matter, only to die on November 24, 1314. His son, Louis X of France sent a mission to disperse the Gascon cardinals and arranged for the cardinals to meet again in Lyon, through the emissary of his brother, Philip, Count of Poitiers (future Philip V of France), in March 1316. However, Louis X died, and Philip—forced to return to Paris to pursue his own interests—locked the cardinals in the Dominican convent of Lyon, leaving the Count of Forez to guard the conclave, on June 28, 1316 (previously, to get the cardinals to assemble, Philip had promised the cardinals that he would not lock them in, but he declared that the threat of schism annulled this promise).
At this point, the Gascon faction put forward the candidacy of a moderate member of their ranks, Arnaud Fournier, who was vetoed by the Count, on the instructions of Philip. The conclave proceeded to deadlock around the nominations of Pellegrue, Mondagout, and Fredol. The impetus for the break of the deadlock was a falling out between Napoleone Orsini and Pietro Colonna, after which the latter threw his support behind the Gascons. According to Prof. Toman, this conclave saw the last appearance of a compromise committee tasked with the selection of a suitable candidate. Jacques d'Euse was elected on August 7, taking the name John XXII as a compromise candidate with the votes of some of the Italian faction (who had begun to fear the influence of the Colonna) and some of the Gascons; d'Euse was also supported by the Count and by Robert of Naples; the vote was made unanimous after an accessus, with the remaining cardinals relenting due to d'Euse's advanced age (72).
With Pope John XXII reopening the disputed cases before the curia on October 1 in Avignon, the location of the papacy within France appeared to be secured permanently, as the percentage of Italians within the College was only expected to decline further. Whereas, John XXII had been expected to die quickly, he lived until 1334, reaching the age of 90. John XXII's early disputes with the Franciscans (whom he persecuted due to their views on poverty) and Ludwig of Bavaria (whose claim to the Holy Roman Empire he disputed) merged together when Louis proclaimed John XXII deposed in Rome and, with the assistance of an electorate of thirteen Roman clergy, chose a Franciscan Pietro da Corbara as Antipope Nicholas V on April 18, 1328. John XXII's standing in the Curia further diminished late in his papacy when he promoted the unpopular theological view that Saints would not meet God until the Last Judgment.
Whereas Clement V had lived as a guest in the Dominican monastery of Avignon, John XXII began the construction of the Palais des Papes on the bank of the Rhone in the Comtat Venaissin. Five more French popes were elected in succession—Benedict XII (1334–1342), Clement VI (1342–1352), Innocent VI (1352–1362), Urban V (1362–1370), and Gregory XI (1370–1378)—remaining in Avignon and growing the French super-majority within the College. When the papacy did return to Rome after the return of Gregory XI to Italy to pursue his property claims in the Papal States during the War of the Eight Saints, the result was the Western Schism.