is a polypeptide
secreted by PP cells
in the endocrine pancreas
predominantly in the head of the pancreas
. It consists of 36 amino acids
and has molecular weight about 4200 Da
The function of PP is to self regulate the pancreas secretion activities (endocrine and exocrine), it also effects on hepatic glycogen levels and gastrointestinal secretions.
Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.