The unincorporated community of Panamint Springs is located along State Route 190 (SR190) between Old Toll Road and SR178/Panamint Valley Road in Inyo County, California. The community features a motel, restaurant, and the last gas station for many miles in either direction on SR190.
Although not official by the Board of Geographic Names, Caltrans calls the SR178/SR190 intersection, Panamint Junction. The junction is about 2.5 driving miles east of Panamint Springs. Towne Pass, a landmark when traveling to Death Valley, is 13.9 driving miles east on SR190. Beyond the pass, SR190 descends about to the dry bed of Lake Manly.
The Darwin Falls Wilderness, a U.S. Wilderness Area, is located just west of the settlement. The nearby area also features the Darwin Falls, a small but scenic waterfall, grotto and creek that are the only year-round water supply in the driest part of North America; despite the similarly named wilderness, the falls are located in and administered by Death Valley National Park. The dirt road entryway to the trail to Darwin Falls is located ¼ mile west of the settlement.