) or pamidronate disodium
), pamidronate disodium pentahydrate
is a nitrogen containing bisphosphonate
, used to prevent osteoporosis
. It is marketed by Novartis
under the brand name Aredia
It is used to prevent bone
loss, and treat osteoporosis
. It is also used to strengthen bone in Paget's disease
, to prevent bone loss due to steroid
use, and in certain cancers
with high propensity to bone, such as multiple myeloma
. In multiple myeloma, it is usually administered as an intravenous infusion, lasting about 3 hours. The therapy is repeated monthly, and lasts for the life of the patient. Due to its ability to sequester calcium
in bone, it is also used to treat high calcium levels
It is also used as an experimental treatment of the bone disorder known as Osteogenesis Imperfecta
, or brittle bones.
, usually 90 mg monthly. 30 mg, 60 mg, and 90 mg vials are available, mixed with mannitol
Common side effects include bone pain, low calcium levels
, and dizziness
Osteonecrosis of the jaw
is a rare complication which has been associated with the use of bisphosphonates, including pamidronate.
Pamidronate activates human γδ T cells in vitro and in vivo, which may lead to flu-like symptoms upon administration.