She had several starring roles in American films in the early 1960s, including One, Two, Three; State Fair and Come Fly with Me. She co-stared with Paul Newman in Harper in 1966. The February 1969 issue of Playboy did a photo feature on her entitled "A Toast to Tiffin". From 1965 to 1974 she appeared mainly in European exploitation films before retiring to be with her family. She appeared, as herself, in the 2003 documentary, Abel Ferrara: Not Guilty, opposite her daughter, Echo Danon.
Pamela Tiffin starred in two missing teen films by American International Pictures; For Those Who Think Young with James Darren, Bob Denver and Tina Louise (both from Gilligan's Island), Nancy Sinatra, Paul Lynde and Ellen Burstyn and The Lively Set with James Darren and Doug McClure, film music and lyrics by Bobby Darin. Both movies were made around 1964. Tiffin also played an ingenue opposite Tony Franciosa in the film "The Pleasure Seekers" which also starred Carol Lynley and Ann Margret.
(1) Clay Felker, the late American magazine editor, whom she married in 1962 and divorced in 1969.
(2) Edmondo Danon, a philosopher, who is a son of the Italian movie producer Marcello Danon. They married in 1974 and have two daughters, Echo and Aurora.