P-bodies

P-bodies

Processing bodies (also called GW or Dcp bodies) are regions within the cytoplasm of the eukaryotic cell consisting of many enzymes involved in mRNA turnover. P bodies are likely the site of miRNA action, as miRNA-targeted mRNAs are recruited to P bodies and degraded or sequestered from translational machinery.

The following activities of p-bodies were demonstrated:

  • degrade unwanted mRNAs that lack a 5' cap
  • store mRNA until needed for translation
  • aid in translational repression by miRNAs (related to siRNAs)

New evidence by Hoyle et al suggests a novel site termed EGP bodies may be responsible for mRNA storage as these sites lack the decapping enzyme.

References

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