Oxoglutarate dehydrogenase (NADP )

Oxoglutarate dehydrogenase (NADP+)

In enzymology, an oxoglutarate dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + CoA + NADP+ rightleftharpoons succinyl-CoA + CO2 + NADPH

The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and NADP+, whereas its 3 products are succinyl-CoA, CO2, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating). This enzyme is also called oxoglutarate dehydrogenase (NADP+).


  • Inui H, Miyatake K, Nakano Y, Kitaoka S "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". J. Biochem. 931–4.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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