, an oxoglutarate dehydrogenase (NADP+)
is an enzyme
the chemical reaction
- 2-oxoglutarate + CoA + NADP+ succinyl-CoA + CO2 + NADPH
The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and NADP+, whereas its 3 products are succinyl-CoA, CO2, and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating). This enzyme is also called oxoglutarate dehydrogenase (NADP+).
- Inui H, Miyatake K, Nakano Y, Kitaoka S "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". J. Biochem. 931–4.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes