Definitions

Olopatadine

Olopatadine

{{drugbox | IUPAC_name = {(11Z)-11-[3-(dimethylamino)propylidene]-6,11-
dihydrodibenzo[b,e]oxepin-2-yl}acetic acid | image = Olopatadine.svg | CAS_number = 113806-05-6 | ATC_prefix = S01 | ATC_suffix = GX09 | ATC_supplemental = | PubChem = 5281071 | DrugBank = APRD00310 | C = 21 |H = 23 |N = 1 |O = 3 | molecular_weight = 337.412 g/mol | smiles = CN(C)CC/C=C1/c2cc(ccc2OCc2ccccc12)CC(=O)O | bioavailability = | protein_bound = | metabolism = | elimination_half-life = 3 hours | pregnancy_category = C | legal_status = | routes_of_administration = Ophthalmic, intranasal, oral }} Olopatadine hydrochloride is an antihistamine and mast cell stabilizer, sold as a prescription eye drop (0.2% solution, trademark Pataday (or Patanol S in some countries), manufactured by Alcon). It is used to treat itching associated with allergic conjunctivitis (eye allergies). Olopatadine hydrochloride 0.1% is sold as trademark Patanol (or Opatanol in some countries). A nasal spray formulation is sold as trademark Patanase, which was approved by the FDA on April 15, 2008. It is also available as an oral tablet in Japan under the tradename Allelock, manufactured by Kyowa Hakko Kogyo.

It should not be used to treat irritation caused by contact lenses. The usual dose for trademark Pataday is 1 drop in each affected eye once a day. The usual dose for trademark Patanol is 1 drop in each affected eye 2 times per day, with 6 to 8 hours between doses.

Its side effects may include headaches (7% of occurrence) burning and stinging (5%), dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pruritus, asthenia, cold syndrome, pharyngitis, rhinitis, sinusitis, and taste change.

Olopatadine was developed by Kyowa Hakko Kogyo.

References

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