Oleoyl-estrone (OE) is a fatty acid ester of estrone. It is a naturally circulating hormone in animals including humans. It was first reported in 1996 to cause a body fat loss effect in rats in the International Journal of Obesity and Related Metabolic Disorders. The animal research has all been conducted by the Nitrogen-Obesity Research Group of the University of Barcelona.
The compound was found to potently induce body-fat loss while preserving protein stores in animals which is the ultimate goal of an anti-obesity agent as body protein loss is an undesired but inevitable (to some degree) side effect of fat loss via calorie restriction.
The research group discovered that oleoyl-estrone levels correlated with bodyfat stores except for obese organisms where there was less oleoyl-estrone circulating than would be predicted based on bodyfat levels. This led to the theory that administering oleoyl-estrone to bring plasma OE levels up to normal would signal to the body that there is an excess amount of bodyfat and therefore there would be a bodyfat loss.
The research group set up a company called Oleoyl-Estrone Developments in 2001 which included as a founder Dr. Marià Alemany, one of the principal researches, who is also the holder of a 1998 U.S. patent for fatty acid esters of estrone, including OE, in relation to fat loss.
The group studied the effects of oral OE on Dr. Marià Alemany who was morbidly obese. It was shown for the first time to be effective at producing fat loss in a human and also a maintenance (and increase) of weight loss in two-month rest periods in between three-week dosing periods. This was achieved with no prescribed dietary restrictions.
In June 2006 a Phase IIa trial of 100 patients began which included two 14-day dosing periods each followed by 28 days of no treatment which was designed to elucidate the best dosing methods and in particular the maintenance of weight loss that had been shown. This trial was originally a single-centre trial in Switzerland, but in November 2006 it was announced that the trial had been expanded to two additional clinical sites in the USA. The results from this trial are expected in the first half of 2007.
An additional trial was commenced in October 2006 that is designed to investigate the efficacy of the drug in morbidly obese patients who had been designated as bariatric patient candidates. This trial, taking place in the USA, will recruit 24 patients and will dose OE for 30 days, without any break, and then have a follow-up 30 days after dosing has been completed. The results from this trial are also expected in the first half of 2007.
Short-term oleoyl-estrone treatment affects capacity to manage lipids in rat adipose tissue.(Research article)(Report)
Aug 28, 2007; Authors: Anna Salas ; Véronique Noé ; Carlos J Ciudad ; M Mar Romero ; Xavier Remesar (corresponding author) [1,3];...
Treatment of pregnant rats with oleoyl-estrone slows down pup fat deposition after weaning.(Research)(Clinical report)
Jun 20, 2008; Authors: Beatriz García-Peláez ; Ruth Vilà [1,2]; Xavier Remesar (corresponding author) [1,2] Background The administration of...