Southern Culture on the Skids released a cover.
The 1970 album After the Gold Rush by Neil Young contains a much slower and more melancholy version of this song, compared with the original.
In 1989, the Kentucky Headhunters recorded a cover version of "Oh Lonesome Me" on their album Pickin' on Nashville. This cover was released as a single in 1990, reaching a peak of #8 on the Hot Country Singles & Tracks charts.
Roger Miller does a cover on Classic Country 1950-1959.
Johnny Cash recorded a version of the song at Sun Records.