1-acylglycerophosphocholine O-acyltransferase

acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine $rightleftharpoons$ CoA + 1,2-diacyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

• Bell RM, Coleman RA "Enzymes of glycerolipid synthesis in eukaryotes". Annu. Rev. Biochem. 49 459–87.
• Hill EE, Lands WE "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine". Biochim. Biophys. Acta. 152 645–8.
• Miki Y, Hosaka K, Yamashita S, Handa H, Numa S "Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes". Eur. J. Biochem. 81 433–41.
• van den Bosch H, van Golde LM, Eibl H, van Deenen LL "The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes". Biochim. Biophys. Acta. 144 613–23.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes