Nucleotide sugar metabolism is particularly well-studied in bacterial pathogens, such as E. coli and Mycobacterium tuberculosis, since these molecules are required for the synthesis of glycoconjugates on the surfaces of these organisms. These glycoconjugates are virulence factors and components of the bacterial cell wall. These pathways are also studied in plants, but here the enzymes involved are less well understood.
US Patent Issued to Sloan-Kettering Institute for Cancer on March 15 for "Active-Site Engineering of Nucleotidylyltransferases and General Enzymatic Methods for the Synthesis of Natural and "unnatural" UDP-And TDP-Nucleotide Sugars" (New York, Wisconsin Inventors)
Mar 22, 2011; ALEXANDRIA, Va., March 22 -- United States Patent no. 7,906,460, issued on March 15, was assigned to Sloan-Kettering Institute...