North Andover was first settled, as Andover, in 1646, when the Indian town of Cochichawicke was purchased by the Rev Mr. John Woodbridge (1613-17 March 1694/95) for "£6 and a coat." On 26 May 1647, the General Court appointed John Osgood and Thomas Hale to lay out a road from Andover to Haverhill. The town of North Andover was officially incorporated 7 April 1855.
Due to its location near the city of Lawrence, Massachusetts, North Andover was at one time of minor importance as a mill community with some cotton mills of its own.
During the Salem Witch Trials numerous people from North Andover were accused of witchcraft, more than from Danvers, Massachusetts itself (which was the location of the Salem Witch Trials.)
North Andover originally was the political and religious center of a larger 17th century settlement which today would include Andover, North Andover, and the eastern part of Lawrence. First called Cochiechewick Plantation for the tall trees and rivers, the area was reserved by the General Court in 1634 for an inland plantation; the first settlement was established in 1643 by residents of the coastal towns of Ipswich and Newbury, including the Rev. Mr. John Bradstreet, a minister from Ipswich, John Osgood, John Stevens, William Ballard, John Lovejoy and Thomas Chandler. Although there were boundary changes throughout the 18th century, it was not until 1855 that Andover split into two separate towns, Andover and North Andover. North Andover includes the Old Center which was the North Parish. A subtle rivalry between the two towns still exists today
North Andover borders the following towns: Andover, Lawrence, Haverhill, Boxford, Middleton, and North Reading. North Andover is separated from Methuen by the Merrimack River.
There were 9,724 households out of which 36.8% had children under the age of 18 living with them, 60.2% were married couples living together, 8.5% had a female householder with no husband present, and 29.0% were non-families. 25.1% of all households were made up of individuals and 11.8% had someone living alone who was 65 years of age or older. The average household size was 2.61 and the average family size was 3.16.
In the town the population was spread out with 25.5% under the age of 18, 9.5% from 18 to 24, 29.1% from 25 to 44, 22.6% from 45 to 64, and 13.4% who were 65 years of age or older. The median age was 37 years. For every 100 females there were 92.9 males. For every 100 females age 18 and over, there were 87.1 males.
The median income for a household in the town was $72,728, and the median income for a family was $91,105. Males had a median income of $66,793 versus $38,495 for females. The per capita income for the town was $34,335. 2.9% of the population and 2.1% of families were below the poverty line. 2.7% of those under the age of 18 and 4.1% of those 65 and older are living below the poverty line.