Nitrate reductase (NAD(P)H)

Nitrite reductase (NAD(P)H)

In enzymology, a nitrite reductase [NAD(P)H] is an enzyme that catalyzes the chemical reaction

ammonium hydroxide + 3 NAD(P)+ + H2O rightleftharpoons nitrite + 3 NAD(P)H + 3 H+

The 4 substrates of this enzyme are ammonium hydroxide, NAD+, NADP+, and H2O, whereas its 4 products are nitrite, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ammonium-hydroxide:NAD(P)+ oxidoreductase. Other names in common use include nitrite reductase (reduced nicotinamide adenine dinucleotide, (phosphate)), NADH-nitrite oxidoreductase, NADPH-nitrite reductase, assimilatory nitrite reductase, nitrite reductase [NAD(P)H2], and NAD(P)H2:nitrite oxidoreductase. This enzyme participates in nitrogen metabolism. It has 3 cofactors: FAD, Iron, and Siroheme.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .


  • Cammack R, Jackson RH, Cornish-Bowden A, Cole JA "Electron-spin-resonance studies of the NADH-dependent nitrite reductase from Escherichia coli K12". Biochem. J. 207 333–9.
  • Lazzarini RA and Atkinson DE "A triphosphopyridine nucleotide-specific nitrite reductase from Escherichia coli". J. Biol. Chem. 236 3330–3335.
  • Nicholas DJD, Medina A and Jones OTG "A nitrite reductase from Neurospora crassa". Biochim. Biophys. Acta 37 468.
  • Taniguchi H, Mitsui H, Nakamura K and Egami F "Ann. Acad. Sci. Fenn. Ser. A II 60 (1955) 200".
  • Colandene JD, Garrett RH "Functional dissection and site-directed mutagenesis of the structural gene for NAD(P)H-nitrite reductase in Neurospora crassa". J. Biol. Chem. 271 24096–104.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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