Nicholson Road is a major north-south road in the southeastern suburbs of Perth, Western Australia, connecting Albany Highway in Cannington with the large residential areas of Thornlie and Canning Vale, before leaving the Perth urban area and terminating in Oakford. Until the construction of Kwinana Freeway to Thomas Road in 1993, Nicholson Road was one of southern Perth's most important routes.

Major Intersections

• Spencer Road - Langford, Thornlie, Huntingdale, Gosnells
• Metcalfe Road - Ferndale, Parkwood
• High Road - Parkwood, Riverton, Willetton
• Roe Highway - Forrestfield, Perth Airport
• Ranford Road - Willetton, Murdoch University / Armadale
• Warton Road - Jandakot / Huntingdale
• Armadale Road - Jandakot / Armadale
• Thomas Road - Kwinana / Byford