Neuropeptide Y receptor

Neuropeptide Y receptor

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.


There are five known mammalian neuropeptide y receptors designated Y1 through Y5. Four neuropeptide y receptors each encoded by a different gene have been identified in humans:


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