Neoliberalism is a response to Neorealism; while not denying the anarchic nature of the international system, neoliberals argue that its importance and effect has been exaggerated. The neoliberal argument is focused on the neorealists' underestimation of "the varieties of cooperative behavior possible within... a decentralized system. Both theories, however, consider the state and its interests as the central subject of analysis; Neoliberalism may have a wider conception of what those interests are.
Neoliberalism argues that even in an anarchic system of autonomous rational states, cooperation can emerge through the building of norms, regimes and institutions.
In terms of the scope of international relations theory and foreign interventionism, the debate between Neoliberalism and Neorealism is an intra paradigm one, as both theories are positivist and focus mainly on the state system as the primary unit of analysis.
The heart of Keohane and Nye’s argument is that in international politics there are, in fact, multiple channels that connect societies exceeding the conventional Westphalian system of states. This manifests itself in many forms ranging from informal governmental ties to multinational corporations and organizations. Here they define their terminology; interstate relations are those channels assumed by realists; transgovernmental relations occur when one relaxes the realist assumption that states act coherently as units; transnational applies when one removes the assumption that states act coherently. It is through these channels that political exchange occurs, not through the limited interstate channel as championed by realists.
Secondly, Keohane and Nye argue that there is not, in fact, a hierarchy among issues, meaning that not only is the martial arm of foreign policy not the supreme tool by which to carry out a states agenda, but that there are a multitude of different agendas that come to the forefront. The line between domestic and foreign policy becomes blurred in this case, as realistically there is no clear agenda in interstate relations.
Finally, the use of military force is not exercised when complex interdependence prevails. The idea is developed that between countries in which a complex interdependence exists, the role of the military in resolving disputes is negated. However, Keohane and Nye go on to state that the role of the military is in fact important to that "alliance’s political and military relations with a rival bloc."
Keohane and Lisa L. Martin expound upon these ideas in the mid 1990s as a response to John J. Mearsheimer’s, “The False Promise of International Institutions,” where Mearsheimer purports that, “institutions cannot get states to stop behaving as short-term power maximizers.” In fact Mearsheimer’s article is a direct response to the liberal-institutionalist movement created in response to neo-realism. The central idea in Keohane and Martin’s idea is that neo-realism insists that, “institutions have only marginal effects…[which] leaves it [neo-realism] without a plausible account of the investments that states have made in such international institutions as the EU, NATO, GATT, and regional trading organizations.” This idea is in keeping with the notion of complex interdependence. Moreover, Keohane and Martin argue that the fact that international institutions are created in response to state interests, that the real empirical question is “knowing how to distinguish the effects of underlying conditions from those of the institutions themselves.”
Mearsheimer, however, is concerned with ‘inner-directed’ institutions, which he states, “seek to cause peace by influencing the behavior of the member states.” In doing so he dismisses Keohane and Martin’s NATO argument in favor of the example of the European Community (EC) and the International Energy Agency. According to Mearsheimer, the NATO argument is an alliance and is interested in “an outside state, or coalition of states, which the alliance aims to deter, coerce, or defeat in war.” Mearsheimer reasons that since NATO is an alliance it has special concerns and concedes this point to Keohane and Martin.
Mearsheimer attacks Martin’s research on the EC, particularly her argument on Argentine sanctions by Britain during the Falklands war, which were affected by Britain’s linking of issues in context of the EC. Mearsheimer purports that the United States was not a member of the EC and yet the US and Britain managed to cooperate on sanctions, effectively creating an ad hoc alliance which effected change in its member states.