Neddylation is the process by which the ubiquitin like protein Nedd8 is conjugated to its target proteins. This process is analogous to ubiquitination, although relies on its own E1 and E2 enzymes. No Nedd8 specific E3 has yet been identified and it is possible that the Neddylation system relies on E3 ligases with dual specificity.

NEDD8

Neddylation process

Disease association

Neddylation is involved in the pathogenesis of Alzheimer's Disease where its activation seems to drive neurons into apoptosis by initiating cell cycle reentry.

Further reading

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