The NPR-A was created by President Warren G. Harding in 1923 as "Naval Petroleum Reserve Number 4" during a time when the United States was converting its navy to run on oil rather than coal. In 1976 the Naval Petroleum Reserves Production Act renamed the reserve the "National Petroleum Reserve in Alaska" and transferred it from the Navy to the Department of the Interior. The 1980 Interior Department Appropriations Act directed the Bureau of Land Management (BLM) within the Department of Interior to conduct oil and gas leasing. Nevertheless, the area was left essentially as a wilderness until the late 1990s.
BLM divided the reserve into three planning areas: the Northeast with of public land, the Northwest with of public land, and the South with of public land. In 1998, after BLM had gone through a planning process for the Northeast area, the Secretary of Interior signed a Record of Decision (ROD), which opened 87 percent of this area to oil and gas leasing. BLM has since leased almost in the Northeast. A ROD for the Northwest area was signed in 2004. In this area have been leased. BLM began the planning process for the South in 2005, but discontinued it in the summer of 2007 because residents were concerned that extraction of oil and gas would harm resources needed for subistence.
In 2008 the plan for the Northeast area is in the process of being changed. The ROD for the Northeast reserved 800,000 acres (3200 km²) of the most ecologically sensitive areas, mostly around Teshekpuk, as a wildlife reserve. In January 2005, the George W. Bush administration decided to eliminate the reservations for the most sensitive areas. This decision was challenged by lawsuits. On September 7 2006, the US District Court in Anchorage blocked the sale of leases on 600,000 acres (2400 km²) of wetland around the Teshekpuk Lake area. In response to the court, BLM released a Supplemental Integrated Activity Plan/Environmental Impact Statement. The agency is expected to issue a final supplemental statement in the spring of 2008 and may hold a lease sale for the Teshekpuk area in the fall of 2008.
The conservation movement as a whole has put less effort into preserving the NPR-A than it has into protecting the smaller Arctic National Wildlife Refuge to its east. A citizens' proposal to conserve the entire NPR-A as a National Pleistocene Refuge, with no future oil and gas leasing, has been put forward. Other conservation initiatives have concentrated on specific areas within the NPR-A that are particularly rich in wildlife such as the Teshekpuk area and the wetlands along the Ikpikpuk River in the Northwest. As of early 2008, these campaigns have not achieved any permanent successes, despite the fact that a committee of the National Research Council in 2003 published a report that supports environmental claims that oil and gas extraction in the reserve causes extensive environmental damage.