Napolitano (modern Italian "Napoletano") is translated in English as Neapolitan. The word can refer to people from Napoli (Naples), their language, culture in addition to being an Italian surname.

People with the surname:

• Andrew Napolitano, a former judge and current correspondent for Fox News Channel
• Angelina Napolitano, the first person in Canada to use the battered woman defense for murder
• Danilo Napolitano, an Italian cyclist
• Giorgio Napolitano, President of the Italian Republic
• Grace Napolitano, an American politician, a Democratic member of the United States House of Representatives
• Janet Napolitano, the current governor of the U.S. state of Arizona
• Johnette Napolitano, the lead singer and songwriter and bassist of Concrete Blonde
• Michael Napolitano, the Mayor of Cranston, Rhode Island
• Norberto Napolitano, known by the pseudonym Pappo, an Argentine blues and rock musician
• Sonny Black Napolitano, a capo in the Bonanno crime family
• Luigi G. Napolitano Award, a prize awarded by IAF
• Mario Napolitano, an Italian chess player