Talese is Senior Vice President of Doubleday and the Publisher and Editorial Director of Nan A. Talese/Doubleday. At Random House and earlier at Simon & Schuster and Houghton Mifflin, she has had editorial relationships with Pat Conroy, Margaret Atwood, Ian McEwan, Barry Unsworth and Thomas Keneally. Her imprint also published James Frey's discredited memoir A Million Little Pieces.
She has two daughters: Pamela (a painter), and Catherine (a photographer).