omain containing 2
) is a protein
, also known as the caspase recruitment domain
family, member 15 (CARD15), which plays an important role in the immune system
. It is an intracellular pattern recognition receptor
, which is similar in structure to resistant proteins
of plants and recognizes molecules containing the specific structure called muramyl dipeptide
(MDP) that is found in certain bacteria
The NOD2 gene is linked to inflammatory diseases such as inflammatory bowel disease/Crohn's Disease and Blau syndrome.
It is located on chromosome 16 in humans.