NAD(P) --protein-arginine ADP-ribosyltransferase

NAD(P)+-protein-arginine ADP-ribosyltransferase

In enzymology, a NAD(P)+-protein-arginine ADP-ribosyltransferase is an enzyme that catalyzes the chemical reaction using nicotinamide adenine dinucleotide

NAD+ + protein L-arginine rightleftharpoons nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine NADP+ + protein L-arginine rightleftharpoons nicotinamide + Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine

as well as the corresponding reaction using nicotinamide adenine dinucleotide phosphate

NADP+ + protein L-arginine rightleftharpoons nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine NADP+ + protein L-arginine rightleftharpoons nicotinamide + Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine

Thus, the two substrates of this enzyme are NAD+ (or NADP+) and protein L-arginine, whereas its two products are nicotinamide and Nomega-(ADP-D-ribosyl)-protein-L-arginine (or Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine, respectively).

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase. Other names in common use include ADP-ribosyltransferase, mono(ADP-ribosyl)transferase, NAD+:L-arginine ADP-D-ribosyltransferase, NAD(P)+-arginine ADP-ribosyltransferase, NAD(P)+-arginine ADP-ribosyltransferase, and NAD(P)+:L-arginine ADP-D-ribosyltransferase.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .

References

  • Moss J, Stanley SJ, Oppenheimer NJ "Substrate specificity and partial purification of a stereospecific NAD- and guanidine-dependent ADP-ribosyltransferase from avian erythrocytes". J. Biol. Chem. 254 8891–4.
  • Moss J, Stanley SJ, Watkins PA "Isolation and properties of an NAD- and guanidine-dependent ADP-ribosyltransferase from turkey erythrocytes". J. Biol. Chem. 255 5838–40.
  • Ueda K, Hayaishi O "ADP-ribosylation". Annu. Rev. Biochem. 54 73–100.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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