N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

In enzymology, a N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase is an enzyme that catalyzes the chemical reaction

3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O rightleftharpoons 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

The 5 substrates of this enzyme are ATP, L-2-aminohexanedioate, L-cysteine, L-valine, and H2O, whereas its 3 products are AMP, diphosphate, and [[N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine]].

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting). Other names in common use include L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, ACV synthetase, and L-alpha-aminoadipyl-cysteinyl-valine synthetase. This enzyme participates in penicillin and cephalosporin biosynthesis.


  • Byford MF, Baldwin JE, Shiau CY, Schofield CJ "The Mechanism of ACV Synthetase". Chem. Rev. 97 2631–2650.
  • Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J "Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum". Biochem. J. 327 185–91.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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