Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute renal insufficiency.
McArdle's Disease is another cause of myoglobinuria.
Research from University of Chicago, Department of Human Genetics in myoglobinuria immunology provides new insights.
May 05, 2010; Investigators publish new data in the report 'Episodic Myoglobinuria in a primary gamma-sarcoglycanopathy.' According to...