Recently, Denmark et al. have developed an enantioselective catalyst for aymmetric Passerini reactions.
This mechanism involves a trimolecular reaction between the isocyanide (R-NC), the carboxylic acid, and the carbonyl in a sequence of nucleophilic additions . The transition state TS# is depicted as a 5-membered ring with partial covalent or double bonding. The second step of the Passerini reaction is an acyl transfer to the neighboring hydroxyl group. There is support for this reaction mechanism: the reaction proceeds in relatively non-polar solvents (in line with transition state) and the reaction kinetics depend on all three reactants. This reaction is a good example of a convergent synthesis.
Researchers from China University provide details of new studies and findings in the area of chemical engineering.
Nov 04, 2009; According to recent research published in the journal Industrial & Engineering Chemistry Research, "A one-dimensional isothermal...