Muldestausee-Schmerzbach is a Verwaltungsgemeinschaft ("collective municipality") in the district of Anhalt-Bitterfeld, in Saxony-Anhalt, Germany. It is situated on the right bank of the Mulde, east of Bitterfeld. It is named after the reservoir in the river Mulde in its territory. The seat of the Verwaltungsgemeinschaft is in Schlaitz.

The Verwaltungsgemeinschaft Muldestausee-Schmerzbach consists of the following municipalities:

1. Burgkemnitz
2. Gossa
3. Gröbern
4. Krina
5. Muldenstein
6. Plodda
7. Pouch
8. Rösa
9. Schlaitz
10. Schwemsal