He then directed a few other films which did not do well until he won acclaim for the Scarface-inspired crime thriller Agneepath (1990) with Amitabh Bachchan in the lead role which won Amitabh a National Award for Best Actor. His next notable film was the family drama Hum (1991) also with Bachchan in the lead which was a huge success. He worked with Bachchan again for the final time in the epic film Khuda Gawah (1992) which won him the Filmfare Best Director Award. His last completed film was Trimurti (1995) which had a multi starcast including Jackie Shroff, Anil Kapoor and Shahrukh Khan but failed to do well at the box office becoming one of his biggest flops. The last film he was working on at the time of his death was the much-hyped action adventure film Dus which remained incomplete and unreleased after his death although the film's music did end up releasing.
Mukul died of a heart attack at the age of 45 in September 1997. At the time of his death he was in the middle of filming the action movie Dus in Utah. The climax scenes and some action sequences were being filmed from May 1997 and 40% of the shooting had been completed by August. After his death the film was left incomplete. and never released. Promo videos and clips from what was shot of the film can be seen on his official website which is maintained by his wife Anita and sister Beena.