Moore was raised in Kansas City and then moved to New York City early in the 1920s; she moved often in that decade, working in Chicago, Dallas and Oklahoma City. She played with Charlie Johnson's ensemble at Small's Paradise, and recorded with him in 1927-28. Her output from 1923-27 amounts to 44 tunes, some recorded under the name Susie Smith; her sidemen included Tommy Ladnier, Jimmy O'Bryant, Jimmy Blythe, Bob Fuller, Rex Stewart, Bubber Miley, and Elmer Snowden.
In the 1930s, Moore recorded with Fats Waller (1932), filled in for Ethel Waters as an understudy, and sang with Zinky Cohn in Chicago in 1937. Around 1940 she sang in New York with Sidney Bechet and Sammy Price, and then moved to Los Angeles in 1942, where she performed often in nightclubs. She appeared in James P. Johnson's revue Sugar Hill and appeared in numerous films in minor roles. Moore recorded again in 1945-47. She played with the Young Men of New Orleans at Disneyland in 1961-62, and died of a heart attack that year.