Mirab Wellega is bordered on the south by the Gambela Region, on the west by Sudan, on the north by the Benishangul-Gumuz Region, on the east for a short space by Misraq Welega, and on the southeast by Illubabor. Its highest point is Mount Welel. Towns and cities in Mirab Welega include Dembidolo, Gimbi, Mendi, and Nejo.
The Central Statistical Agency (CSA) reported that 40,606 tons of coffee were produced in Mirab and Misraq Welega combined in the year ending in 2005, based on inspection records from the Ethiopian Coffee and Tea authority. This represents 35.3% of the Region's output and 17.9% of Ethiopia's total output.
Omotic languages are spoken in this zone, particularly Mao in the north and a Kaffa dialect in the south.
According to a May 24, 2004 World Bank memorandum, 7% of the inhabitants of Mirab Welega have access to electricity, this zone has a road density of 38.5 kilometers per 1000 square kilometers (compared to the national average of 30 kilometers), the average rural household has 1.2 hectare of land (compared to the national average of 1.01 hectare of land and an average of 1.14 for the Oromia Region) and the equivalent of 0.8 heads of livestock. 20.7 % of the population is in non-farm related jobs, compared to the national average of 25% and a Regional average of 24%. 71% of all eligible children are enrolled in primary school, and 29% in secondary schools. 87% of the zone is exposed to malaria, and 71% to Tsetse fly. The memorandum gave this zone a drought risk rating of 369.