She was born on February 26, 1974 to Tarlac congressman and current Philippine Olympic Committee president Jose "Peping" Cojuangco, Jr. and Tarlac governor Margarita "Tingting" de los Reyes-Cojuangco. Her father is from a famous Cojuangco family which has mixed Kapampangan, Chinese, and Spanish blood. The Conjuangco family owns a vast sugar plantation in Tarlac known as Hacienda Luisita. She is also the niece of former Philippine President Corazon Cojuangco-Aquino.
Mikee started to show interest in riding at age eight but was only allowed to take lessons by her parents when she turned 10. At the age of 16, she joined her first international competition at Shizuoka, Japan where she placed third in the individual show jumping. But her best winning moment happened just before the curtains fell on the 2002 Asian Games in Busan, South Korea. Mikee managed to bag Philippines' third and last gold medal in the individual show jumping event.
Aside from being a champion rider, Mikee is also a TV and movie actress and a commercial model. She is married to Pasig City congressman Robert "Dudut" Jaworski, Jr., son of basketball player and senator Robert "Sonny" Jaworski. Together, they have three sons named Robert Vincent Anthony III (Robbie), Rafael Joseph (Raf) and Renzo Mikael.