Meyer Kupferman was born in New York City. A self taught composer, Kupferman first gained attention in the late 1940s when his early opera "In A Garden" was premiered at the Tanglewood and Edinburgh Festivals. From 1951 to 1993 he was on the faculty of Sarah Lawrence College. He also served as Chairman of the Music Department for five terms. Kupferman began music at the age of five on violin. As an adult he claimed little memory of his violin instruction, but at age 10 he began to play the clarinet. He taught himself piano and studied music theory at The High School of Music & Art in New York City, subsequently attending Queens College in New York.
As a young man Kupferman played jazz in bars and clubs on Coney Island, and arranged for big bands. In 1951 he was hired as Professor of Composition and Chamber Music at Sarah Lawrence College, a position he held until 1994. In the 1950s he began to experiment with twelve-tone row techniques, and in 1961 devised his "Infinities Row," which would become the only tone row he used in subsequently in his major works. The row is G-F-Ab-B-Bb-D-F#-E-C-Eb-A-C#. In 1990 he published Atonal Jazz.
Much of Kupferman's music contains large gestures and short dramatic hooks which are a critical to his compositional technique (his "gestalt form"). His works are eclectic syntheses of disparate elements. Their extremes of contrast, and outrageousness were reflections of his personal life. Kupferman once jokingly bragged bout smuggling clandestinely made recordings of his music from behind the Iron Curtain.
Kupferman resided in in Rhinebeck, New York, where he and his wife Pei-Fen welcomed members of the community. On the day before Thanksgiving, 2003, he died of heart failure.