|Acetyl-CoA (citric acid cycle) is converted to acetoacetyl-CoA||thiolase|
|Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA).||HMG-CoA synthase|
|HMG-CoA is reduced to mevalonate by NADPH. This reaction occurs in the cytosol. It is the rate limiting step in cholesterol synthesis, which is why the enzyme catalyzing the reaction is a target of statins.||HMG-CoA reductase|
|Mevalonate to 5-phosphomevalonate.||mevalonate kinase|
|5-phosphomevalonate to 5-pyrophosphomevalonate.||phosphomevalonate kinase|
|Mevalonate-5-pyrophosphate to 3-isopentenyl pyrophosphate (IPP) (see also HIDS).|| ||mevalonate-5-pyrophosphate decarboxylase|
|3-isopentenyl pyrophosphate is isomerized to dimethylallyl pyrophosphate.||isopentenyl pyrophosphate isomerase|
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.(Research article)(Report)
Jan 28, 2009; Authors: Louise A Knight ; Christian M Kurbacher ; Sharon Glaysher ; Augusta Fernando ; Ralf Reichelt ; Susanne...
US Patent Issued to Danisco US, the Goodyear Tire & Rubber on Jan. 29 for "Increased Isoprene Production Using the Archaeal Lower Mevalonate Pathway" (American, Danish Inventors)
Feb 05, 2013; ALEXANDRIA, Va., Feb. 5 -- United States Patent no. 8,361,762, issued on Jan. 29, was assigned to Danisco US Inc. (Palo Alto,...
Anti-malarial drug targets: screening for inhibitors of 2C-methyl-D-erythritol 4-phosphate synthase (IspC protein) in Mediterranean plants.
Apr 01, 2007; Abstract The recently discovered non-mevalonate pathway of isoprenoid biosynthesis serves as the unique source of terpenoids in...
Synthesis of the oxysterol, 24( S ), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol.
Apr 05, 2007; Authors: Jenny Wong ; Carmel M Quinn ; Andrew J Brown (corresponding author)  Background Oxygenated cholesterol...