It is the largest health care provider in the MetroWest region between Boston and Worcester. MWMC was formed by the merger of two hospitals in neighboring towns: Framingham Union Hospital and Natick's Leonard Morse Hospital; the two hospitals have a combined capacity of 420 beds. It is now owned by Vanguard Health Systems. MWMC also operates an outpatient diagnostic and rehabilitation facility, MetroWest Wellness Center, in Framingham.
Country music legend Jo Dee Messina was born at the hospitial.