Methylthioadenosine nucleosidase

Methylthioadenosine nucleosidase

In enzymology, a methylthioadenosine nucleosidase is an enzyme that catalyzes the chemical reaction

S-methyl-5'-thioadenosine + H2O rightleftharpoons S-methyl-5-thio-D-ribose + adenine

Thus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and H2O, whereas its two products are S-methyl-5-thio-D-ribose and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-methyl-5'-thioadenosine adeninehyrolase. Other names in common use include 5'-methylthioadenosine nucleosidase, MTA nucleosidase, MeSAdo nucleosidase, and methylthioadenosine methylthioribohydrolase. This enzyme participates in urea cycle and metabolism of amino groups and methionine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .


  • Guranowski AB, Chiang PK, Cantoni GL "5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds". Eur. J. Biochem. 114 293–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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