• Mesa, an elevated area of land with a flat top, surrounded on all sides by steep cliffs
• Mesa (microelectronics), a structure with a shape similar to the geological formation, except created on a semiconductor substrate
• Mesa transistor

Places

• Mesa, Arizona, a city in Maricopa County
• Mesa, California, a census-designated place in Inyo County
• Mesa County, Colorado
• Mesa, Colorado, an unincorporated town
• Mesa, Washington, a city in Franklin County
• Mesa, Mozambique

Software

• Mesa (programming language), a procedural programming language
• Mesa 3D, an open-source implementation of OpenGL

People

• José Mesa, major league pitcher
• Raúl Mesa, Spanish beach volleyball player
• Mesa, portuguese band

Other uses

• Mesa Airlines
• Mesa Boogie (also known as Mesa Engineering), a manufacturer of guitar amplifiers
• Black Mesa Research Facility, a fictional complex in the computer game Half-Life
• Mesa (Honorverse), a fictional star nation dabbling in genetic engineering and slavery
• Mesa, a chain of restaurants in the United States and Bahamas owned by chef Bobby Flay

Acronym

• Middle East Studies Association of North America
• MESA International (Manufacturing Enterprise Solutions Association), an association of end users, vendors and manufacturing professionals, promoting innovation and best practices sharing, with a goal of delivering valuable knowledge around operations-centric enterprise solutions.
• Mathematics, Engineering, Science Achievement, an academic preparation program that is devoted to encouraging educationally disadvantaged students to pursue science, technology, engineering, and math-related studies.
• Multi-Ethnic Study of Atherosclerosis, a medical research study sponsored by the National Heart, Lung, and Blood Institute.