• Megalomania, often used loosely to mean having delusional fantasies of wealth, power, or omnipotence.
• Megalomania (album), by the Russian band Aria
• Megalomania, album by the Norwegian band Enslavement of Beauty
• Mega Lo Mania, a 1991 multi-platform Real-time strategy game by Sensible Software
• Megalomania (novel), a 1989 science-fiction novel by the author Ian Wallace
• Megalomania (film), a 2000 short-length comedy starring Chris Parnell and Ian Abercrombie
• Megalomaniac (song), a 2004 single by the band Incubus from their album A Crow Left of the Murder...

Other recordings have been titled Megalomania as well, including:

• A track on Muse's 2001 album Origin of Symmetry
• A track on Black Sabbath's 1975 album Sabotage
• A track on Pele's 1992 album Fireworks
• First track on KMFDM's 1996 album Symbols.
• A track by Yoko Shimomura for the 1994 Squaresoft game Live-A-Live
• Single released by punk band The Blood, also on "false gestures for a devious public" album
• Incubus' Megalomaniac