Mechanically gated ion channel

Cyclic nucleotide-gated ion channel

A cyclic nucleotide-gated (CNG) ion channel is any ion channel that opens in the presence of cyclic nucleotides.


The channels are gated by a chemical ligand (the cyclic nucleotide), but they are more similar in structure to the family of voltage-gated ion channels than to the ligand gated ones. In fact, the cyclic nucleotide-gated channels often have positively- or negatively-charged areas that may respond to changes in membrane potential. The purpose and function of these charged areas are not yet fully understood.


Cyclic nucleotide-gated channels are particularly important in several systems:



"Cyclic nucleotide gated channel alpha" subunits include

Beta-subunits include:


Other examples include the following "hyperpolarization-activated cyclic nucleotide-gated potassium channels" (HCN channels): HCN1, HCN2, HCN3, HCN4


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